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Veröffentlicht am: | 17.06.2019 |
Position: | One-year post-doctoral Position in organic chemistry/radiochemistry - Development of radiohalogenated L-tyrosine analogues for SPECT / PET imaging of solid tumours |
Arbeitsort: |
Research Laboratory: UMR1240, Université Clermont Auvergne (UCA) – INSERM, Imagerie Moléculaire et Stratégies Théranostiques (IMoST) Fondation de la Maison de la Chimie, Clermont-Ferrand (Frankreich) |
Beschreibung: | Scientific background: Amino acids transporters (AATs) are plasmic membrane proteins that ensure the supply of essential amino acids (AAs) into the cell. Compared to normal ones, cancer cells often present a rapid growth and a high proliferation rate. This can be achieved by an increase of the expression and/or upregulation of AATs at the surface of malignant cells. This difference between normal and cancer cells can be exploited for the development of powerful diagnostic tools in cancer research. Functional imaging is a non-invasive technique allowing the visualization of primary lesions and distant metastases with radiotracers labelled with γ or β+ emitting radionuclides. A promising strategy is the use of radiolabelled analogues of AAs that intensively accumulate in AATs overexpressing tumour cells to achieve high contrast SPECT or PET imaging of tumours. Project: The research team Tatoo « Targets and Tools for imaging and therapy » of UMR INSERM 1240 is currently developing radiotracers targeting these overexpressed AATs at the surface of cancer cells. The aim of this project is the production of radioiodinated and radiofluorinated analogues of L-tyrosine for SPECT or PET imaging of solid tumours. It can rely on organic syntheses and radiosyntheses of the iodinated compounds, which were previously performed in our laboratory during a PhD thesis. The person, to be recruited on this one-year post-doctoral position, will be in charge of completing this study and promoting the results achieved through publication and oral presentations in congresses. The main challenge will be the production of the corresponding fluorinated compounds and the optimization of their fluorine-18 radiolabelling by nucleophilic substitution of diaryliodonium salts precursors. With this view and taking into account that the aromatic nucleophilic radiofluorination of electron-rich aromatic amino acids remains a real challenge in radiochemistry, an innovative method was recently developed for the nucleophilic radiofluorination of the well-known [18F]FDOPA, which is structurally close to compounds designed in this project (see Maisonial-Besset, A ; Serre, A. et al. Eur. J. Org. Chem., 2018: 7058-7065. doi:10.1002/ ejoc.201801608). |
Qualifizierung: | Required candidate profile: For this post-doctoral position in a multidisciplinary environment (chemistry/radiochemistry/biology), we are searching for serious candidates, holder of a PhD diploma, with a good scientific background and practical experience in organic chemistry and if possible in radiochemistry. |
Vergütung in EUR: | Gross salary: 48 500 euros per year |
Bewerbungsschluß: | 15.07.2019 |
Zusätzliche Information: | Environment: The UMR 1240 INSERM UCA is a multidisciplinary group composed of chemists, radiochemists, pharmacologists, biologists and clinicians engaged in cancer research programs. One of its main research areas is the development of innovative radiopharmaceuticals for molecular imaging or targeted radionuclide therapy. To achieve these goals, our lab has all the equipment and facilities for the syntheses/radiosyntheses to the pharmacological evaluation of radiotracers. Regarding the organic chemistry and radiochemistry domains, dedicated rooms and equipment commonly used to carry out multistep chemical (radio)syntheses and to realize the structural determination of produced compounds are available. |
Bewerbungsadresse: | Application deadline: 15/07/2019, urgent recruitment. Contact : aurelie.maisonial@uca.fr |